In a large mixing bowl, mix together the honey, soy sauce, ginger, and garlic powder until completely combined. Add the salmon filets to the bowl and toss until coated. Cover the bowl and refrigerate for at least 15 minutes and up to 4 hours.
When ready to cook, preheat the oven to 400 degrees F and line a baking sheet with parchment paper or foil.
Place salmon filets on to the lined baking sheet, skin side down, and bake for 10-15 minutes or until the internal temperature of the salmon is at least 145 degrees F.
Remove and allow to rest 5 minutes before serving.